Pub. Date : 2021 Sep 3
PMID : 34479471
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our previous studies showed that high-glucose and hypoxic conditions could upregulate HIF-1alpha expression and enhance EC inflammatory injury, independently of the nuclear factor kappa-B (NF-kappaB) pathway. | Glucose | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | RESULTS: High glucose and hypoxia up-regulated HIF-1alpha expression, and down-regulated HIF-1alpha decreased the level of inflammation and oxidative stress in HUVECs. | Glucose | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | RESULTS: High glucose and hypoxia up-regulated HIF-1alpha expression, and down-regulated HIF-1alpha decreased the level of inflammation and oxidative stress in HUVECs. | Glucose | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Moreover, we observed that HIF-1alpha bound to the promoter of JMJD1A, and the ameliorative effects of si-HIF-1alpha on oxidative stress and inflammatory cytokines in high-glucose and hypoxia-induced HUVECs were reversed by JMJD1A overexpression. | Glucose | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | Moreover, we observed that HIF-1alpha bound to the promoter of JMJD1A, and the ameliorative effects of si-HIF-1alpha on oxidative stress and inflammatory cytokines in high-glucose and hypoxia-induced HUVECs were reversed by JMJD1A overexpression. | Glucose | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 6 | CONCLUSIONS: These findings provide novel evidence that the HIF-1alpha/JMJD1A signaling pathway is involved in inflammation and oxidative stress in HUVECs induced by high glucose and hypoxia. | Glucose | hypoxia inducible factor 1 subunit alpha | Homo sapiens |