Title : Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma.

Pub. Date : 2021 Aug 30

PMID : 34462431






1 Functional Relationships(s)
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1 Gene expression profiling and metabolomic analysis reveal that MYCN promotes pyrimidine nucleotide production by transcriptional upregulation of DHODH and other enzymes of the pyrimidine-synthesis pathway. Pyrimidine Nucleotides MYCN proto-oncogene, bHLH transcription factor Homo sapiens