Title : Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis.

Pub. Date : 2021 Aug 28

PMID : 34447675






1 Functional Relationships(s)
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1 Activation of PXR by pregnenolone 16alpha-carbonitrile increased AFB1-induced liver tumor incidence by up-regulating oncogenic KRAS to enhance interleukin (IL)-11:IL-11 receptor subunit alpha-1 (IL11RA-1)-mediated inflammation in an HBx transgenic model. Pregnenolone Carbonitrile nuclear receptor subfamily 1 group I member 2 Homo sapiens