Protein Name nuclear receptor subfamily 1 group I member 2
Organism Homo sapiens
Gene ID 8856
Gene Symbol


UniProt O75469 (NR1I2_HUMAN), F1D8P9 (F1D8P9_HUMAN)
Relationships Total Number of functionally related compound(s) : 820
Total Number of Articles : 1103

nuclear receptor subfamily 1 group I member 2

Gene Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

  • nuclear receptor subfamily 1 group I member 2
  • orphan nuclear receptor PAR1
  • orphan nuclear receptor PXR
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