| Protein Name | nuclear receptor subfamily 1 group I member 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8856 |
| Gene Symbol | NR1I2 |
| UniProt | O75469 (NR1I2_HUMAN), F1D8P9 (F1D8P9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
820
Total Number of Articles : 1103 |
Description |
nuclear receptor subfamily 1 group I member 2 |
| Gene Summary |
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] |
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