Title : Thrombin Inhibition Prevents Endothelial Dysfunction and Reverses 20-HETE Overproduction without Affecting Blood Pressure in Angiotensin II-Induced Hypertension in Mice.

Pub. Date : 2021 Aug 12

PMID : 34445374






1 Functional Relationships(s)
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1 Dabigatran"s effects on endothelial function in Ang II-treated mice were evidenced by improved NO-dependent relaxation in the aorta in response to acetylcholine in vivo (MRI measurements) and increased systemic NO bioavailability (NO2- quantification) with a concomitant increased ex vivo production of endothelium-derived NO (EPR analysis). Acetylcholine angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus