Pub. Date : 2021 Aug 5
PMID : 34445110
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer. | Docetaxel | epidermal growth factor receptor | Homo sapiens |
| 2 | Moreover, SH003 and DTX induced the apoptosis of H460 cells via the suppression of the EGFR and signal transducer and activator of transcription 3 (STAT3) signaling pathways. | Docetaxel | epidermal growth factor receptor | Homo sapiens |
| 3 | In H460 tumor xenograft models, the administration of SH003 or docetaxel alone diminished tumor growth, and their combination effectively killed cancer cells, with increased expression of apoptotic markers and decreased expression of p-EGFR and p-STAT3. | Docetaxel | epidermal growth factor receptor | Homo sapiens |