Title : Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance.

Pub. Date : 2021 Aug 24

PMID : 34433035






1 Functional Relationships(s)
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1 Here, we show that deficiency of HIF-2alpha in macrophages results in excessive activation of the NLRP3 inflammasome in a manner dependent on CPT1A-mediated enhancement of fatty acid oxidation (FAO). Fatty Acids carnitine palmitoyltransferase 1a, liver Mus musculus