Title : Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation.

Pub. Date : 2021 Oct

PMID : 34426410






1 Functional Relationships(s)
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1 Here, we used in vitro transport studies in Transwell , in combination with our m-f PBPK model, to predict fetal Kp,uu of drugs that are effluxed by placental P-glycoprotein (P-gp), namely dexamethasone, betamethasone, darunavir and lopinavir. Lopinavir ATP binding cassette subfamily B member 1 Homo sapiens