Title : High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation.

Pub. Date : 2021 Sep

PMID : 34412779






1 Functional Relationships(s)
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1 Co-treatment with 5-aza-2"-deoxycytidine (a DNA methylation inhibitor) attenuated the high temperature-induced masculinizing effect, recovered the expression of esr1 and sox9b, suppressed the transcription of dnmt3a1 and dnmt3a2, and decreased the methylation of esr1 and sox9b promoter, further confirming that DNA methylation plays an important role in high temperature-induced masculinization of zebrafish. Decitabine DNA (cytosine-5-)-methyltransferase 3 alpha b Danio rerio