Title : Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer.

Pub. Date : 2021 Dec 5

PMID : 34411894






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The most promising compound 40 could markedly reverse the resistance in 5-FU-resistant HCT116 cells and 5-FU-resistant SW620 cells via inhibiting the expression of dihydropyrimidine dehydrogenase (DPD). Fluorouracil dihydropyrimidine dehydrogenase Homo sapiens
2 The most promising compound 40 could markedly reverse the resistance in 5-FU-resistant HCT116 cells and 5-FU-resistant SW620 cells via inhibiting the expression of dihydropyrimidine dehydrogenase (DPD). Fluorouracil dihydropyrimidine dehydrogenase Homo sapiens
3 The most promising compound 40 could markedly reverse the resistance in 5-FU-resistant HCT116 cells and 5-FU-resistant SW620 cells via inhibiting the expression of dihydropyrimidine dehydrogenase (DPD). Fluorouracil dihydropyrimidine dehydrogenase Homo sapiens
4 The most promising compound 40 could markedly reverse the resistance in 5-FU-resistant HCT116 cells and 5-FU-resistant SW620 cells via inhibiting the expression of dihydropyrimidine dehydrogenase (DPD). Fluorouracil dihydropyrimidine dehydrogenase Homo sapiens
5 The key was that compound 40 with improved pharmacokinetic properties significantly increased the inhibitory rate of 5-FU in the SW620/5-FU cells xenograft model with no observable toxicity by inhibiting the expression of DPD in tumor and liver tissues. Fluorouracil dihydropyrimidine dehydrogenase Homo sapiens