Title : Induction of Apoptosis and Inhibition of EGFR/NF-κB Signaling Are Associated With Regorafenib-sensitized Non-small Cell Lung Cancer to Cisplatin.

Pub. Date : 2021 Sep-Oct

PMID : 34410944






5 Functional Relationships(s)
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1 Induction of Apoptosis and Inhibition of EGFR/NF-kappaB Signaling Are Associated With Regorafenib-sensitized Non-small Cell Lung Cancer to Cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens
2 RESULTS: Cisplatin-induced epidermal growth factor receptor (EGFR)/nuclear factor kappaB (NF-kappaB) signaling was effectively inhibited by regorafenib treatment. Cisplatin epidermal growth factor receptor Homo sapiens
3 RESULTS: Cisplatin-induced epidermal growth factor receptor (EGFR)/nuclear factor kappaB (NF-kappaB) signaling was effectively inhibited by regorafenib treatment. Cisplatin epidermal growth factor receptor Homo sapiens
4 Regorafenib, erlotinib (EGFR inhibitor) and QNZ (NF-kappaB inhibitor) may all enhance the cytotoxicity effect of cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens
5 CONCLUSION: Apoptosis induction and EGFR/NF-kappaB inactivation correlate with regorafenib-enhanced anti-NSCLC efficacy of cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens