Pub. Date : 2021 Aug
PMID : 34407950
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK). | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | The drug ezetimibe inhibits NPC1L1-mediated absorption of cholesterol, lowering of circulating levels of low-density lipoprotein cholesterol. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | Here, we report cryo-electron microscopy structures of human NPC1L1 (hNPC1L1) bound to either cholesterol or a lipid resembling VE. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 5 | Here, we report cryo-electron microscopy structures of human NPC1L1 (hNPC1L1) bound to either cholesterol or a lipid resembling VE. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 6 | These findings, together with functional assays, reveal that the same intramolecular channel in hNPC1L1 mediates transport of VE and cholesterol. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 7 | Mutation of tryptophan-347 lies in this region disrupts dimerization and the resultant monomeric NPC1L1 exhibits reduced efficiency of cholesterol uptake. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 8 | These findings identify the oligomeric state of hNPC1L1 as a target for therapies that inhibit uptake of dietary cholesterol and reduce the incidence of cardiovascular disease. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |