PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34407950-0	2021	Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.	Cholesterol	71-82	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	28-34	
34407950-1	2021	Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK).	Cholesterol	97-108	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	34-40	
34407950-2	2021	The drug ezetimibe inhibits NPC1L1-mediated absorption of cholesterol, lowering of circulating levels of low-density lipoprotein cholesterol.	Cholesterol	58-69	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	28-34	
34407950-3	2021	Here, we report cryo-electron microscopy structures of human NPC1L1 (hNPC1L1) bound to either cholesterol or a lipid resembling VE.	Cholesterol	94-105	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	61-67	
34407950-3	2021	Here, we report cryo-electron microscopy structures of human NPC1L1 (hNPC1L1) bound to either cholesterol or a lipid resembling VE.	Cholesterol	94-105	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	69-76	
34407950-4	2021	These findings, together with functional assays, reveal that the same intramolecular channel in hNPC1L1 mediates transport of VE and cholesterol.	Cholesterol	133-144	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	96-103	
34407950-6	2021	Mutation of tryptophan-347 lies in this region disrupts dimerization and the resultant monomeric NPC1L1 exhibits reduced efficiency of cholesterol uptake.	Cholesterol	135-146	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	97-103	
34407950-7	2021	These findings identify the oligomeric state of hNPC1L1 as a target for therapies that inhibit uptake of dietary cholesterol and reduce the incidence of cardiovascular disease.	Cholesterol	113-124	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	48-55