Pub. Date : 2021 Aug 18
PMID : 34407851
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis. | Inositol | insulin | Homo sapiens |
| 2 | BACKGROUND: Multiple oral insulin-sensitizing agents, such as metformin, thiazolidinediones, inositols, and berberine, have been proven safe and efficacious in improving the endocrine, metabolic, and reproductive abnormalities seen in polycystic ovary syndrome (PCOS), providing more options for healthcare providers and patients. | Inositol | insulin | Homo sapiens |
| 3 | Thiazolidinediones, metformin + thiazolidinediones, and myo-inositol + D-chiro-inositol were associated with a lower insulin resistance index (HOMA-IR) compared with that in metformin alone (mean differences: - 0.72 (95% CI (- 1.11)-(- 0.34)) to - 0.89 (95% CI (- 1.460)-(- 0.32))). | Inositol | insulin | Homo sapiens |
| 4 | Thiazolidinediones, metformin + thiazolidinediones, and myo-inositol + D-chiro-inositol were associated with a lower insulin resistance index (HOMA-IR) compared with that in metformin alone (mean differences: - 0.72 (95% CI (- 1.11)-(- 0.34)) to - 0.89 (95% CI (- 1.460)-(- 0.32))). | Inositol | insulin | Homo sapiens |
| 5 | CONCLUSIONS: Ours is the first study to report that for women with PCOS, myo-inositol combined with D-chiro-inositol and metformin combined with thiazolidinediones appear superior to metformin alone in improving insulin resistance and decreasing total testosterone. | Inositol | insulin | Homo sapiens |
| 6 | CONCLUSIONS: Ours is the first study to report that for women with PCOS, myo-inositol combined with D-chiro-inositol and metformin combined with thiazolidinediones appear superior to metformin alone in improving insulin resistance and decreasing total testosterone. | Inositol | insulin | Homo sapiens |