Pub. Date : 2021 Aug 13
PMID : 34392152
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cd increased the acetylation level of RelA K310 and enhanced BRD4 binding to acetylated NF-kappaB RelA in vivo and in vitro, which were abrogated by inhibiting BRD4. | Cadmium | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |
| 2 | Cd increased the acetylation level of RelA K310 and enhanced BRD4 binding to acetylated NF-kappaB RelA in vivo and in vitro, which were abrogated by inhibiting BRD4. | Cadmium | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |
| 3 | In summary, our study suggests that BRD4 is involved in Cd-triggered transcription of inflammatory cytokines by mediating the activation of NF-kappaB signaling pathway and increasing itself binding to acetylated NF-kappaB RelA in rat kidney, therefore, BRD4 could be a potential therapeutic target for Cd-induced renal diseases. | Cadmium | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |