Protein Name RELA proto-oncogene, NF-kB subunit
Organism Rattus norvegicus
Gene ID 309165
Gene Symbol

Rela

UniProt Q7TQN4 (Q7TQN4_RAT)
Relationships Total Number of functionally related compound(s) : 238
Total Number of Articles : 241
Description

RELA proto-oncogene, NF-kB subunit

Gene Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to cobalamin. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; fatty liver disease; and status epilepticus. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and uveitis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • transcription factor p65
  • nuclear factor kappa B subunit p65
  • nuclear factor kappaB subunit p65
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Properties