Title : Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance.

Pub. Date : 2021 Oct

PMID : 34390780






4 Functional Relationships(s)
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1 The study aimed to characterize the role of PPARalpha in alcohol detoxification. Alcohols peroxisome proliferator activated receptor alpha Mus musculus
2 PPARalpha reactivation by Wy14,643 effectively reversed alcohol-induced liver damage in mice. Alcohols peroxisome proliferator activated receptor alpha Mus musculus
3 Notably, PPARalpha activation completely switched alcohol metabolism from the CYP2E1 pathway to the catalase pathway along with accelerated alcohol clearance. Alcohols peroxisome proliferator activated receptor alpha Mus musculus
4 Notably, PPARalpha activation completely switched alcohol metabolism from the CYP2E1 pathway to the catalase pathway along with accelerated alcohol clearance. Alcohols peroxisome proliferator activated receptor alpha Mus musculus