Pub. Date : 2021 Sep
PMID : 34386088
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Anthelminthic niclosamide inhibits tumor growth and invasion in cisplatin-resistant human epidermal growth factor receptor 2-positive breast cancer. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
2 | The present study aimed to determine whether niclosamide can inhibit cell proliferation, invasion and epithelial-to-mesenchymal transition, as well as the stem-like phenotype in cisplatin-resistant HER2-positive breast cancer. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
3 | The results from the present study demonstrated that niclosamide inhibited the resistance of HER2-positive breast cancer to cisplatin both in vitro and in vivo. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
4 | Taken together, the results of the present study suggested that niclosamide combined with cisplatin may be considered as a novel treatment for chemoresistant HER2-positive breast cancer. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |