Title : Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer.

Pub. Date : 2021 Aug 12

PMID : 34385422






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cells bearing BAK/MCL1 complexes were more sensitive to paclitaxel and the MCL1 antagonist S63845. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Cells bearing BAK/MCL1 complexes were more sensitive to paclitaxel and the MCL1 antagonist S63845. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Further studies indicated that cells with preformed BAK/MCL1 complexes were sensitive to the paclitaxel/S63845 combination, while cells without BAK/MCL1 complexes were not. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens