Title : GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK.

Pub. Date : 2021 Aug 10

PMID : 34380027






1 Functional Relationships(s)
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1 Pharmacological PPARbeta/delta activation increases GDF15 levels and ameliorates glucose intolerance, fatty acid oxidation, endoplasmic reticulum stress, and inflammation, and activates AMPK in HFD-fed mice, whereas these effects are abrogated by the injection of a GDF15 neutralizing antibody and in Gdf15-/- mice. Fatty Acids peroxisome proliferator activated receptor alpha Mus musculus