Title : Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression.

Pub. Date : 2022 Jan

PMID : 34379869






2 Functional Relationships(s)
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1 When NFs were incubated with conditioned medium from CAFs, the resulting CAF-educated fibroblasts (CEFs) generated reactive oxygen species (ROS), which induced NF-kappaB-mediated expression of inflammatory cytokines and the extracellular matrix protein asporin (ASPN), while expression of a common CAF marker gene, alpha-SMA, was not increased. Reactive Oxygen Species nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 When NFs were incubated with conditioned medium from CAFs, the resulting CAF-educated fibroblasts (CEFs) generated reactive oxygen species (ROS), which induced NF-kappaB-mediated expression of inflammatory cytokines and the extracellular matrix protein asporin (ASPN), while expression of a common CAF marker gene, alpha-SMA, was not increased. Reactive Oxygen Species nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus