Title : Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-κB.

Pub. Date : 2021 Sep

PMID : 34373714






6 Functional Relationships(s)
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1 In conclusion, PA promoted the TLR4/phosphorylated-NF-kappaB signaling pathway by inhibiting KLF4, promoted the upregulation of Gal-3 expression and improved the insulin resistance of macrophages. Palmitic Acid insulin Homo sapiens
2 Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-kappaB. Palmitic Acid insulin Homo sapiens
3 The insulin resistance of macrophages was induced by palmitic acid (PA) in vitro. Palmitic Acid insulin Homo sapiens
4 The insulin resistance of macrophages was induced by palmitic acid (PA) in vitro. Palmitic Acid insulin Homo sapiens
5 The results revealed that PA-induced macrophages demonstrated insulin resistance. Palmitic Acid insulin Homo sapiens
6 The addition of the Gal-3 inhibitor GB1107 significantly increased glucose utilization and reduced insulin resistance in PA-treated cells. Palmitic Acid insulin Homo sapiens