Title : 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.

Pub. Date : 2021 Sep 20

PMID : 34369548






1 Functional Relationships(s)
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1 In vitro assays revealed that treatment with 18beta-GA considerably suppressed the expression of pro-inflammatory mediators and cytokines, including prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and interleukin-6 (IL-6), which were induced by IL-1beta. Nitric Oxide interleukin 1 alpha Mus musculus