Pub. Date : 2021 Oct
PMID : 34369032
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice. | idebenone | src homology 2 domain-containing transforming protein C1 | Mus musculus |
| 2 | Idebenone was recently identified as the first small-molecule Shc inhibitor drug. | idebenone | src homology 2 domain-containing transforming protein C1 | Mus musculus |
| 3 | In the fibrotic MCD NASH model, idebenone reduced Shc expression and phosphorylation in peripheral blood mononuclear cells and Shc expression in the liver; decreased serum alanine aminotransferase and aspartate aminotransferase; and attenuated liver fibrosis as observed by quantitative polymerase chain reaction (qPCR) and hydroxyproline quantification. | idebenone | src homology 2 domain-containing transforming protein C1 | Mus musculus |
| 4 | In the fibrotic MCD NASH model, idebenone reduced Shc expression and phosphorylation in peripheral blood mononuclear cells and Shc expression in the liver; decreased serum alanine aminotransferase and aspartate aminotransferase; and attenuated liver fibrosis as observed by quantitative polymerase chain reaction (qPCR) and hydroxyproline quantification. | idebenone | src homology 2 domain-containing transforming protein C1 | Mus musculus |