Pub. Date : 2021
PMID : 34347777
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Furthermore, we demonstrated direct inhibition of paclitaxel-induced ABCB1 transporter activity by both lapatinib and poziotinib. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In conclusion, lapatinib and poziotinib combined with paclitaxel synergizes to inhibit the proliferation of ABCB1-overexpressing ovarian cancer cells in vitro. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |