Title : Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels.

Pub. Date : 2021 Nov

PMID : 34347342






3 Functional Relationships(s)
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1 In line with PAH status, pulmonary microvessels in monocrotaline-treated animals demonstrated significant (p<0.05, n=6 per group) upregulation of alphaSMA (two fold) and downregulation of BMPR2 (20%). Monocrotaline bone morphogenetic protein receptor type 2 Rattus norvegicus
2 MQCM and Western blot analysis showed that monocrotaline-induced ZIP12 upregulation could be partially negated by BMPR2-targeted therapy. Monocrotaline bone morphogenetic protein receptor type 2 Rattus norvegicus
3 Our results indicate that altered zinc transport/storage and S1P signalling in the monocrotaline-induced PAH rat model are linked to each other, and could be alleviated by BMPR2-targeted therapy. Monocrotaline bone morphogenetic protein receptor type 2 Rattus norvegicus