Title : Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA.

Pub. Date : 2021 Aug 3

PMID : 34344439






1 Functional Relationships(s)
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1 Mechanistically, sustained AKT signaling drives lapatinib resistance in cells with the kinase domain mutation, as demonstrated by staining for the intracellular product of PI3-kinase, PIP3. Lapatinib AKT serine/threonine kinase 1 Homo sapiens