Title : β 2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2.

Pub. Date : 2021 Oct

PMID : 34341099






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 beta2-Adrenoceptor Agonists Promote ERK1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-driven Signaling Independently of beta-Arrestin 2. Cyclic AMP adrenoceptor beta 2 Homo sapiens
2 Collectively, these results contest the hypothesis that formoterol activates ERK1/2 in airway epithelia by nucleating a betaArr2 signaling complex; instead, they indicate that beta2-adrenoceptor agonists inhibit constitutive ERK1/2 activity in a cAMP-dependent manner. Cyclic AMP adrenoceptor beta 2 Homo sapiens
3 Moreover, these effects were PKA-dependent suggesting that beta2-adrenoceptor agonists were not biased toward beta-arrestin 2 and acted via canonical, cAMP-dependent signaling. Cyclic AMP adrenoceptor beta 2 Homo sapiens