Title : miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.

Pub. Date : 2021 Oct

PMID : 34339961






3 Functional Relationships(s)
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1 miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-kappaB pathway. Cisplatin nuclear factor kappa B subunit 1 Homo sapiens
2 Mechanistically, the SIRT1 expression was suppressed and the NF-kappaB signaling pathway was activated by the upregulation of miR-132-3p in cisplatin-induced AKI. Cisplatin nuclear factor kappa B subunit 1 Homo sapiens
3 Our results suggested that miR-132-3p exacerbated cisplatin-induced AKI by negatively regulating SIRT1 and activating the NF-kappaB signaling pathway. Cisplatin nuclear factor kappa B subunit 1 Homo sapiens