Title : Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice.

Pub. Date : 2021 Sep 1

PMID : 34338042






4 Functional Relationships(s)
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1 Tissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that mediate this phenotype are not completely understood. Iron insulin Homo sapiens
2 Macrophages (Mphi)s are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mphis impairs mitochondrial energetics and evokes systemic insulin resistance in mice. Iron insulin Homo sapiens
3 Macrophages (Mphi)s are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mphis impairs mitochondrial energetics and evokes systemic insulin resistance in mice. Iron insulin Homo sapiens
4 These findings also suggest that if Mphis are capable of storing iron properly, they have a pronounced ability to withstand iron excess without evoking overt collateral damage and associated insulin resistance that may be age dependent. Iron insulin Homo sapiens