Title : Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.

Pub. Date : 1987 Nov

PMID : 3433801






1 Functional Relationships(s)
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1 The imidazole antifungal agents, ketoconazole, miconazole and clotrimazole have been shown to be potent inhibitors of the phenobarbital-induced cytochromes P-450 and the 3-methylcholanthrene-induced cytochromes P-448-dependent rat hepatic microsomal mixed-function oxidases. Phenobarbital cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus