Title : Developing C2-Aroyl Indoles as Novel Inhibitors of IDO1 and Understanding Their Mechanism of Inhibition via Mass Spectroscopy, QM/MM Calculations and Molecular Dynamics Simulation.

Pub. Date : 2021

PMID : 34336787






1 Functional Relationships(s)
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Protein Name
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1 Indoleamine-2,3-dioxygenase (IDO1) and tryptophan dioxygenases are two heme based metalloenzymes that catalyze the tryptophan oxidation reaction by inserting molecular dioxygen to cleave the pyrrole ring. Pyrroles indoleamine 2,3-dioxygenase 1 Homo sapiens