Title : Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats.

Pub. Date : 2021 Oct

PMID : 34333051






2 Functional Relationships(s)
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1 Intrathecally infusion of the JNK inhibitor SP600125 significantly inhibited SNL-induced upregulation of HDAC2. pyrazolanthrone mitogen-activated protein kinase 8 Rattus norvegicus
2 In cultured astrocytes, TNF-alpha induced enhanced phosphorylation of JNK and a significant increase of HDAC2, as well as a remarkable decrease of GLT-1, which could be prevented by SP600125 or the HDAC2 specific inhibitor CAY10683. pyrazolanthrone mitogen-activated protein kinase 8 Rattus norvegicus