Title : Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss.

Pub. Date : 2021 Sep

PMID : 34331013






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Because addition of the BCL2 inhibitor venetoclax resulted in compensatory upregulation of MCL1, we established a three-drug combination composed of sirolimus, venetoclax, and the MCL1 inhibitor S63845. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens