Title : Detrimental role of IL-33/ST2 pathway sustaining a chronic eosinophil-dependent Th2 inflammatory response, tissue damage and parasite burden during Toxocara canis infection in mice.

Pub. Date : 2021 Jul

PMID : 34324507






3 Functional Relationships(s)
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1 Studies have indicated that Th2 response is the main immune defense mechanism against toxocariasis, however, there are still few studies related to this response, mainly the IL-33/ST2 pathway. th2 interleukin 33 Mus musculus
2 By binding to its ST2 receptor, IL-33 stimulating the Th2 polarized immune cell and cytokine responses. th2 interleukin 33 Mus musculus
3 Collectively, our results demonstrate that the Th2 immune response triggered by IL-33/ST2 pathway mediates susceptibility to T. canis, related to parasitic burden, eosinophilia and granuloma formation in which consequently contributes to tissue inflammation and injury. th2 interleukin 33 Mus musculus