Title : Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway.

Pub. Date : 2021 Sep

PMID : 34321603






1 Functional Relationships(s)
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1 Further study showed that kindlin-2 could specifically bind to p-alpha-Pix(S13) and Rac1 to induce a switch from the inactive Rac1-GDP conformation to the active Rac1-GTP conformation and then stimulate the downstream MAPK pathway. Guanosine Diphosphate FERM domain containing kindlin 2 Homo sapiens