Pub. Date : 2021 Jul 28
PMID : 34321322
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | First, we showed that Chop deletion in beta cells alleviated beta cell ER stress and delayed glucose-stimulated insulin secretion (GSIS) in HFD-fed mice. | Glucose | DNA-damage inducible transcript 3 | Mus musculus |
| 2 | Third, we provide mechanistic evidence that Chop depletion reduces ER Ca2+ buffering capacity and modulates glucose-induced islet Ca2+ oscillations, leading to transcriptional changes of ER chaperone profile ("ER remodeling"). | Glucose | DNA-damage inducible transcript 3 | Mus musculus |