Title : MiRNA-Mediated Knock-Down of Bcl-2 and Mcl-1 Increases Fludarabine-Sensitivity in CLL-CII Cells.

Pub. Date : 2021 Jul 1

PMID : 34319043






3 Functional Relationships(s)
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1 CONCLUSIONS: Our data propose that suppression of Bcl-2 and Mcl-1 by miRNA-15a can effectively inhibit the cell proliferation and sensitize CLL cells to fludarabine. fludarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 MiRNA-Mediated Knock-Down of Bcl-2 and Mcl-1 Increases Fludarabine-Sensitivity in CLL-CII Cells. fludarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 BACKGROUND: Over-expression of anti-apoptotic proteins such as Bcl-2 and Mcl-1 is associated with resistance to chemotherapeutic agents such as fludarabine. fludarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens