Title : Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation.

Pub. Date : 2021 Oct

PMID : 34314916






2 Functional Relationships(s)
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1 The over expression of aldose reductase (ALR2) in the state of hyperglycemia causes the conversion of glucose into sorbitol and initiates polyol pathway. polyol aldo-keto reductase family 1 member B Homo sapiens
2 The over expression of aldose reductase (ALR2) in the state of hyperglycemia causes the conversion of glucose into sorbitol and initiates polyol pathway. polyol aldo-keto reductase family 1 member B Homo sapiens