Title : Synergistic inhibitory effect of Smo inhibitor jervine and its combination with decitabine can target Hedgehog signaling pathway to inhibit myelodysplastic syndrome cell line.

Pub. Date : 2021 Dec

PMID : 34314648






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, after combining both of the drug treatments, the proteins levels of Smo, G1i-1, PI3K, p-AKT, Bcl2, and Cyclin Dl were significantly downregulated, and Caspase-3 is upregulated, indicating that jervine with its combination of decitabine might be effective for controlling the proliferation, apoptosis, and cell cycle. Decitabine BCL2 apoptosis regulator Homo sapiens