Title : Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.

Pub. Date : 2021 Sep 25

PMID : 34311050






2 Functional Relationships(s)
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1 Compared with controls, metformin-treated APP23-ob/ob mice had significantly reduced Abeta levels in the cerebral cortex (p < .05) and hippocampus (p < .05) and increased levels of IDE in the hippocampus (p < .01). Metformin amyloid beta (A4) precursor protein Mus musculus
2 Our results indicate that metformin attenuates the severity of CAA by enhancing Abeta-cleaving IDE expression. Metformin amyloid beta (A4) precursor protein Mus musculus