Title : Perfluorooctane sulfonate interferes with non-genomic estrogen receptor signaling pathway, inhibits ERK1/2 activation and induces apoptosis in mouse spermatocyte-derived cells.

Pub. Date : 2021 Aug

PMID : 34303733






2 Functional Relationships(s)
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1 GC-2 cells were treated with PFOS (0, 50, 100 and 150microM) for 24 h or 48 h. Results demonstrated that PFOS dose-dependently inhibited cell viability, induced G0/G1 cell cycle arrest and triggered apoptosis, which might be partly explained by the decrease in cyclin D1, PCNA and Bcl-2 protein expression; increase in Bax protein expression; and activation of caspase-9, -3. perfluorooctane sulfonic acid BCL2-associated X protein Mus musculus
2 GC-2 cells were treated with PFOS (0, 50, 100 and 150microM) for 24 h or 48 h. Results demonstrated that PFOS dose-dependently inhibited cell viability, induced G0/G1 cell cycle arrest and triggered apoptosis, which might be partly explained by the decrease in cyclin D1, PCNA and Bcl-2 protein expression; increase in Bax protein expression; and activation of caspase-9, -3. perfluorooctane sulfonic acid BCL2-associated X protein Mus musculus