| Protein Name | BCL2-associated X protein |
|---|---|
| Organism | Mus musculus |
| Gene ID | 12028 |
| Gene Symbol | Bax |
| UniProt | Q07813 (BAX_MOUSE), Q544Z6 (Q544Z6_MOUSE), A0A1B0GT81 (A0A1B0GT81_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
1197
Total Number of Articles : 2064 |
Description |
BCL2-associated X protein |
| Gene Summary |
Enables Hsp70 protein binding activity; chaperone binding activity; and identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Part of BAX complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human BAX (BCL2 associated X, apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022] |
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