Title : Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.

Pub. Date : 2021 Oct

PMID : 34291435






1 Functional Relationships(s)
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1 Importantly, we find that in the APP/PS1 mouse model of Alzheimer"s disease (AD), activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Abeta plaque levels and reverses the molecular and behavioral AD phenotypes. Metformin amyloid beta (A4) precursor protein Mus musculus