Pub. Date : 2021
PMID : 34290611
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
2 | Nifedipine, frequently prescribed for hypertension, is a competitive CYP3A5 inhibitor which can inhibit tacrolimus metabolism. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
3 | The objective of this study was to investigate whether CYP3A5 genotype could influence tacrolimus-nifedipine DDI in Chinese renal transplant patients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
4 | Results: In this study, a significant DDI between tacrolimus and nifedipine with respect to the CYP3A5*3 polymorphism was confirmed. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
5 | The co-administrated nifedipine and CYP3A5*3/*3 homozygotes significantly increased tacrolimus concentrations in multivariate line regression analysis. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
6 | Discussion: A CYP3A5 genotype-dependent DDI was found between tacrolimus and nifedipine. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |