Title : Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia.

Pub. Date : 2021 Jul 20

PMID : 34289368






2 Functional Relationships(s)
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1 HMGB1 release inhibition using ethyl pyruvate (EP) and glycyrrhizic acid (GA) prevents TauO-induced senescence through inhibition of p38-mitogen-activated protein kinase (MAPK) and nuclear factor kappaB (NF-kappaB)-the essential signaling pathways for SASP development. Glycyrrhizic Acid high mobility group box 1 Homo sapiens
2 HMGB1 release inhibition using ethyl pyruvate (EP) and glycyrrhizic acid (GA) prevents TauO-induced senescence through inhibition of p38-mitogen-activated protein kinase (MAPK) and nuclear factor kappaB (NF-kappaB)-the essential signaling pathways for SASP development. Glycyrrhizic Acid high mobility group box 1 Homo sapiens