Title : PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling.

Pub. Date : 2021 Sep 1

PMID : 34287090






2 Functional Relationships(s)
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1 Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression. honokiol sirtuin 3 Mus musculus
2 Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression. honokiol sirtuin 3 Mus musculus