Protein Name sirtuin 3
Organism Mus musculus
Gene ID 64384
Gene Symbol


UniProt Q8R104 (SIR3_MOUSE), Q4FJK3 (Q4FJK3_MOUSE)
Relationships Total Number of functionally related compound(s) : 296
Total Number of Articles : 422

sirtuin 3

Gene Summary

Enables NAD-dependent histone deacetylase activity (H3-K14 specific) and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]

  • NAD-dependent protein deacetylase sirtuin-3
  • NAD-dependent deacetylase sirtuin-3
  • SIR2-like protein 3
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