Pub. Date : 2021 Sep 1
PMID : 34287090
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 5 | In-vitro and in-vivo iron treatment resulted in the downregulation of PPARalpha, Sirt3, active beta-catenin and its downstream target gene c-Myc in the mouse liver. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 6 | In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 7 | In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 8 | In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |
| 9 | Thus, our results establish a novel link between hepatic iron and PPARalpha, Sirt3 and beta-catenin signaling. | Iron | peroxisome proliferator activated receptor alpha | Mus musculus |