Title : Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway.

Pub. Date : 2021 Sep

PMID : 34278508






2 Functional Relationships(s)
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1 The results showed that DEX treatment markedly increased the survival rate and neurological score, increased neuron survival, decreased the expression of the LC3, Beclin-1 and NF-kappaB proteins, as well as the cytokines IL-1beta, IL-6 and TNF-alpha, which indicated that DEX-mediated inhibition of autophagy and neuroinflammation ameliorated neuronal death following TBI. Dexmedetomidine tumor necrosis factor Mus musculus
2 The results showed that DEX treatment markedly increased the survival rate and neurological score, increased neuron survival, decreased the expression of the LC3, Beclin-1 and NF-kappaB proteins, as well as the cytokines IL-1beta, IL-6 and TNF-alpha, which indicated that DEX-mediated inhibition of autophagy and neuroinflammation ameliorated neuronal death following TBI. Dexmedetomidine tumor necrosis factor Mus musculus